Version 5.4
Mus musculus Protein: Fblim1
Summary
InnateDB Protein IDBP-270132.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fblim1
Protein Name filamin binding LIM protein 1
Synonyms 2410043F08Rik; Cal; Fblp1; Gt10; migfilin; migfilin(s);
Species Mus musculus
Ensembl Protein ENSMUSP00000101410
InnateDB Gene IDBG-202206 (Fblim1)
Protein Structure
UniProt Annotation
Function Serves as an anchoring site for cell-ECM adhesion proteins and filamin-containing actin filaments. Is implicated in cell shape modulation (spreading) and motility. May participate in the regulation of filamin-mediated cross-linking and stabilization of actin filaments. May also regulate the assembly of filamin- containing signaling complexes that control actin assembly. Promotes dissociation of FLNA from ITGB3 and ITGB7. Promotes activation of integrins and regulates integrin-mediated cell-cell adhesion (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, cell cortex {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cell junction, focal adhesion {ECO:0000250}. Note=Associated with actin stress fiber at cell-ECM focal adhesion sites. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008270 zinc ion binding
GO:0031005 filamin binding
Biological Process
GO:0008360 regulation of cell shape
GO:0016337 single organismal cell-cell adhesion
GO:0033623 regulation of integrin activation
Cellular Component
GO:0001725 stress fiber
GO:0005925 focal adhesion
GO:0005938 cell cortex
GO:0030054 cell junction
GO:0043231 intracellular membrane-bounded organelle
Protein Structure and Domains
PDB ID MGI:1921452
InterPro IPR001781 Zinc finger, LIM-type
PFAM PF00412
PRINTS
PIRSF
SMART SM00132
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q71FD7
PhosphoSite PhosphoSite-Q71FD7
TrEMBL A2ADF4
UniProt Splice Variant
Entrez Gene 74202
UniGene Mm.490327
RefSeq NP_001156728
MGI ID
MGI Symbol Fblim1
OMIM
CCDS CCDS18876
HPRD
IMGT
EMBL AF513359 AK154680 AK170151 AK170440 AL670446 BC004777 CH466615
GenPept AAH04777 AAQ08090 BAE32761 BAE41598 BAE41798 CAM19893 EDL13381 EDL13382 EDL13383 EDL13384 EDL13385 EDL13386

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca