InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Masp2

Summary

InnateDB Protein

IDBP-270321.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Masp2

Protein Name

mannan-binding lectin serine peptidase 2

Synonyms

MAp19; MASP-2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000101326

InnateDB Gene

IDBG-204703 (Masp2)

Protein Structure

UniProt Annotation

Function

Serum protease that plays an important role in the activation of the complement system via mannose-binding lectin. After activation by auto-catalytic cleavage it cleaves C2 and C4, leading to their activation and to the formation of C3 convertase (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Plasma.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004252	serine-type endopeptidase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0048306	calcium-dependent protein binding

Biological Process

GO:0001867	complement activation, lectin pathway
GO:0006508	proteolysis
GO:0006958	complement activation, classical pathway
GO:0045087	innate immune response (InnateDB)