Version 5.4
Mus musculus Gene: Masp2
Summary
InnateDB Gene IDBG-204703.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Masp2
Gene Name mannan-binding lectin serine peptidase 2
Synonyms MAp19; MASP-2
Species Mus musculus
Ensembl Gene ENSMUSG00000028979
Encoded Proteins
IDBP-204705
mannan-binding lectin serine peptidase 2
IDBP-270321
mannan-binding lectin serine peptidase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 22792067
Masp2 deficient mice are defective in the lectin pathway of complement activation and are highly susceptible to pneumococcal infection.
InnateDB Annotation from Orthologs
Summary
PMID 18596036
[Homo sapiens] MASP2 binds to and is activated by MBL or ficolin in response to pathogen-associated molecular patterns (PAMPs).
PMID 16189649
[Homo sapiens] MASP2, upon activation, can cleave complement component 4 (C4) and C2 to generate the C3 convertase, C4bC2b.
PMID 22792067
[Homo sapiens] MASP2 deficient mice are defective in the lectin pathway of complement activation and are highly susceptible to pneumococcal infection. (Demonstrated in mice)
PMID 23785123
[Homo sapiens] MASP2 forms a complex with MASP1 to activate the complement system.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000009724:
The Ra-reactive factor (RARF) is a complement-dependent bactericidal factor that binds to the Ra and R2 polysaccharides expressed by certain enterobacteria. Alternate splicing of this gene results in two transcript variants encoding two RARF components that are involved in the mannan-binding lectin pathway of complement activation. The longer isoform is cleaved into two chains which form a heterodimer linked by a disulfide bond. The encoded proteins are members of the trypsin family of peptidases. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:148602554-148615499
Strand Forward strand
Band E2
Transcripts
ENSMUST00000052060 ENSMUSP00000049729
ENSMUST00000105701 ENSMUSP00000101326
ENSMUST00000154898
ENSMUST00000136647
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001855 complement component C4b binding
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0048306 calcium-dependent protein binding
Biological Process
GO:0001867 complement activation, lectin pathway
GO:0006508 proteolysis
GO:0006958 complement activation, classical pathway
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005576 extracellular region
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000009724
View Gene Order
ENSBTAG00000012808
Not yet available
Pathways
NETPATH
REACTOME
REACT_239142
Innate Immune System pathway
REACT_210497
Creation of C4 and C2 activators pathway
REACT_251891
Ficolins bind to repetitive carbohydrate structures on the target cell surface pathway
REACT_208792
Complement cascade pathway
REACT_230745
Immune System pathway
REACT_247072
Lectin pathway of complement activation pathway
REACT_202834
Initial triggering of complement pathway
KEGG
mmu04610
Complement and coagulation cascades pathway
mmu05150
Staphylococcus aureus infection pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04610
Complement and coagulation cascades pathway
hsa05150
Staphylococcus aureus infection pathway
INOH
PID NCI
Cross-References
SwissProt Q91WP0
TrEMBL
UniProt Splice Variant
Entrez Gene 17175
UniGene Mm.378962
RefSeq NM_001003893 XM_006535927 XM_006538616 NM_010767
OMIM
CCDS CCDS18941 CCDS18942
HPRD
IMGT
MGI ID MGI:1330832
MGI Symbol Masp2
EMBL AB009459 AJ250369 AK050052 AL606969 BC013893 Y19160 Y19163
GenPept AAH13893 BAA34674 BAC34052 CAB63701 CAB65247 CAB65250 CAM21185 CAM21186
RNA Seq Atlas 17175

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca