InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ctnnbip1

Summary

InnateDB Protein

IDBP-270339.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ctnnbip1

Protein Name

catenin beta interacting protein 1

Synonyms

1110008O09Rik; 2310001I19Rik; AW457332; Catnbip1; Icat;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000101317

InnateDB Gene

IDBG-205218 (Ctnnbip1)

Protein Structure

UniProt Annotation

Function

Prevents the interaction between CTNNB1 and TCF family members, and acts as negative regulator of the Wnt signaling pathway.

Subcellular Localization

Cytoplasm. Nucleus.

Disease Associations

Tissue Specificity

Highly expressed in heart, brain, liver and skeletal muscle. Detected at low levels in kidney, testis and lung.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0070016	armadillo repeat domain binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001658	branching involved in ureteric bud morphogenesis
GO:0002528	regulation of vascular permeability involved in acute inflammatory response
GO:0009952	anterior/posterior pattern specification
GO:0016055	Wnt signaling pathway
GO:0030178	negative regulation of Wnt signaling pathway
GO:0031333	negative regulation of protein complex assembly
GO:0032091	negative regulation of protein binding
GO:0043392	negative regulation of DNA binding
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045657	positive regulation of monocyte differentiation
GO:0045669	positive regulation of osteoblast differentiation
GO:0048662	negative regulation of smooth muscle cell proliferation
GO:0060633	negative regulation of transcription initiation from RNA polymerase II promoter
GO:0072201	negative regulation of mesenchymal cell proliferation