InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tnfrsf9

Summary

InnateDB Protein

IDBP-270383.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tnfrsf9

Protein Name

tumor necrosis factor receptor superfamily, member 9

Synonyms

4-1BB; A930040I11Rik; AA408498; AI325004; Cd137; CDw137; ILA; Ly63;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000101296

InnateDB Gene

IDBG-205902 (Tnfrsf9)

Protein Structure

UniProt Annotation

Function

Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Expressed on the surface of activated T-cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	11 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0019955	cytokine binding

Biological Process

GO:0042127	regulation of cell proliferation
GO:0045087	innate immune response (InnateDB)
GO:0070207	protein homotrimerization
GO:2001180	negative regulation of interleukin-10 secretion
GO:2001183	negative regulation of interleukin-12 secretion