InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Plekhg5

Summary

InnateDB Protein

IDBP-270404.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Plekhg5

Protein Name

pleckstrin homology domain containing, family G (with RhoGef domain) member 5

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000101286

InnateDB Gene

IDBG-206297 (Plekhg5)

Protein Structure

UniProt Annotation

Function

Guanine nucleotide exchange factor that activates RHOA and maybe the NF-kappa-B signaling pathway. Involved in the control of neuronal cell differentiation. Plays a role in angiogenesis through regulation of endothelial cells chemotaxis. {ECO:0000269PubMed:16467373, ECO:0000269PubMed:21543326}.

Subcellular Localization

Cytoplasm. Cytoplasm, perinuclear region. Cell junction. Cell projection, lamellipodium. Note=Predominantly cytoplasmic, however when cells are stimulated found in perinuclear regions. Localized at cell-cell junctions in quiescent endothelial cells, it relocalizes to cytoplasmic vesicle and the leading edge of lamellipodia in migrating endothelial cells.

Disease Associations

Tissue Specificity

Expressed in neurons and glial cells of the peripheral nervous system, with highest levels of expression in the brain and sciatic nerve endoneurium. Isoform 2 is expressed at detectable levels only in malignant cells. {ECO:0000269PubMed:16467373, ECO:0000269PubMed:23777631}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005515	protein binding

Biological Process

GO:0007165	signal transduction
GO:0032319	regulation of Rho GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0035767	endothelial cell chemotaxis
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043542	endothelial cell migration

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0030027	lamellipodium
GO:0030139	endocytic vesicle
GO:0048471	perinuclear region of cytoplasm