InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Plekhg5

Summary

InnateDB Gene

IDBG-206297.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Plekhg5

Gene Name

pleckstrin homology domain containing, family G (with RhoGef domain) member 5

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000039713

Encoded Proteins

IDBP-206299

pleckstrin homology domain containing, family G (with RhoGef domain) member 5

IDBP-270402

pleckstrin homology domain containing, family G (with RhoGef domain) member 5

IDBP-270404

pleckstrin homology domain containing, family G (with RhoGef domain) member 5

IDBP-400075

pleckstrin homology domain containing, family G (with RhoGef domain) member 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000171680:
This gene encodes a protein that activates the nuclear factor kappa B (NFKB1) signaling pathway. Mutations in this gene are associated with autosomal recessive distal spinal muscular atrophy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:152072498-152115400

Strand

Forward strand

Band

Transcripts

ENSMUST00000084115	ENSMUSP00000081132
ENSMUST00000105662	ENSMUSP00000101287
ENSMUST00000105661	ENSMUSP00000101286
ENSMUST00000118648	ENSMUSP00000112707
ENSMUST00000123615
ENSMUST00000140085
ENSMUST00000142412

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005515	protein binding

Biological Process

GO:0007165	signal transduction
GO:0032319	regulation of Rho GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0035767	endothelial cell chemotaxis
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043542	endothelial cell migration

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0030027	lamellipodium
GO:0030139	endocytic vesicle
GO:0048471	perinuclear region of cytoplasm