InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Esr1

Summary

InnateDB Protein

IDBP-270554.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Esr1

Protein Name

estrogen receptor 1 (alpha)

Synonyms

AA420328; AU041214; ER-alpha; ER[a]; ERa; ERalpha; ESR; Estr; Estra; Nr3a1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000101213

InnateDB Gene

IDBG-131663 (Esr1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 520 interaction(s) predicted by orthology.

Experimentally validated
Total	31 [view]
Protein-Protein	29 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	520 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005496	steroid binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0030284	estrogen receptor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001547	antral ovarian follicle growth
GO:0002064	epithelial cell development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0008209	androgen metabolic process
GO:0008584	male gonad development
GO:0030522	intracellular receptor signaling pathway
GO:0042981	regulation of apoptotic process
GO:0043401	steroid hormone mediated signaling pathway
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048146	positive regulation of fibroblast proliferation
GO:0060065	uterus development
GO:0060068	vagina development
GO:0060523	prostate epithelial cord elongation
GO:0060527	prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060687	regulation of branching involved in prostate gland morphogenesis
GO:0060745	mammary gland branching involved in pregnancy
GO:0060749	mammary gland alveolus development
GO:0060750	epithelial cell proliferation involved in mammary gland duct elongation
GO:0071391	cellular response to estrogen stimulus

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:1352467

InterPro

IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001292 Oestrogen receptor
IPR001628 Zinc finger, nuclear hormone receptor-type
IPR001723 Steroid hormone receptor
IPR008946 Nuclear hormone receptor, ligand-binding

PFAM

PF00104
PF02159
PF00105

PRINTS

PR00543
PR00047
PR00398

PIRSF

PIRSF500101

SMART

SM00430
SM00399

TIGRFAMs

Post-translational Modifications

Modification

Cross-References