InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: METTL3

Summary

InnateDB Protein

IDBP-2707.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

METTL3

Protein Name

methyltransferase like 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000298717

InnateDB Gene

IDBG-2705 (METTL3)

Protein Structure

UniProt Annotation

Function

N6-methyltransferase that methylates adenosine residues of some mRNAs and acts as a regulator of the circadian clock. N6- methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in the efficiency of mRNA splicing and processing. M6A regulates the length of the ciracadian clock: acts as a early pace-setter in the circadian loop by putting mRNA production on a fast-track for facilitating nuclear processing, thereby providing an early point of control in setting the dynamics of the feedback loop. {ECO:0000269PubMed:22575960, ECO:0000269PubMed:24284625, ECO:0000269PubMed:9409616}.

Subcellular Localization

Nucleus speckle {ECO:0000269PubMed:9409616}. Note=Colocalizes with speckles in interphase nuclei. Suggesting that it may be associated with nuclear pre-mRNA splicing components.

Disease Associations

Tissue Specificity

Widely expressed at low level. Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes. {ECO:0000269PubMed:9409616}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	6 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0008168	methyltransferase activity
GO:0016422	mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity

Biological Process

GO:0001510	RNA methylation
GO:0006139	nucleobase-containing compound metabolic process
GO:0006397	mRNA processing
GO:0007623	circadian rhythm
GO:0010467	gene expression
GO:0019827	stem cell maintenance
GO:0061157	mRNA destabilization
GO:0080009	mRNA methylation