Version 5.4
Homo sapiens Gene: METTL3
Summary
InnateDB Gene IDBG-2705.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol METTL3
Gene Name methyltransferase like 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000165819
Encoded Proteins
IDBP-2707
methyltransferase like 3
IDBP-50093
methyltransferase like 3
IDBP-603075
methyltransferase like 3
IDBP-597514
methyltransferase like 3
IDBP-599347
methyltransferase like 3
IDBP-602760
methyltransferase like 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. This enzyme is involved in the posttranscriptional methylation of internal adenosine residues in eukaryotic mRNAs, forming N6-methyladenosine. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:21498133-21511375
Strand Reverse strand
Band q11.2
Transcripts
ENST00000298717 ENSP00000298717
ENST00000377543 ENSP00000366766
ENST00000367606
ENST00000396522
ENST00000539760 ENSP00000440598
ENST00000544500
ENST00000537163 ENSP00000442407
ENST00000543235 ENSP00000445523
ENST00000544248 ENSP00000437692
ENST00000536201
ENST00000542054
ENST00000545319
ENST00000545788
ENST00000538267
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 6 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0008168 methyltransferase activity
GO:0016422 mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity
Biological Process
GO:0001510 RNA methylation
GO:0006139 nucleobase-containing compound metabolic process
GO:0006397 mRNA processing
GO:0007623 circadian rhythm
GO:0010467 gene expression
GO:0019827 stem cell maintenance
GO:0032259 methylation
GO:0061157 mRNA destabilization
GO:0080009 mRNA methylation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0016607 nuclear speck
GO:0036396 MIS complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022160
View Gene Order
ENSBTAG00000015148
Not yet available
Pathways
NETPATH
REACTOME
REACT_125
Processing of Capped Intron-Containing Pre-mRNA pathway
REACT_71
Gene Expression pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.168799 Hs.665546
RefSeq NM_019852
HUGO
OMIM
CCDS CCDS32044
HPRD 14389
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca