InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cdh23

Summary

InnateDB Protein

IDBP-270834.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cdh23

Protein Name

cadherin 23 (otocadherin)

Synonyms

4930542A03Rik; ahl; ahl1; bob; bus; mdfw; nmf112; nmf181; nmf252; sals; USH1D; v;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000101101

InnateDB Gene

IDBG-154608 (Cdh23)

Protein Structure

UniProt Annotation

Function

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing. {ECO:0000269PubMed:11138008}.

Subcellular Localization

Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.

Disease Associations

Note=Defects in Cdh23 are the cause of waltzer (v) phenotype. Waltzer mice are characterized by deafness and vestibular dysfunction due to degeneration of the neuroepithelium within the inner ear.

Tissue Specificity

In adult animals relatively high levels of expression are found in testis, skeletal muscle, heart, eye and thymus, and lower expression in kidney, lung and brain. Found in the sensory hair cells of the inner ear. {ECO:0000269PubMed:11138008}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0007155	cell adhesion
GO:0007156	homophilic cell adhesion
GO:0007605	sensory perception of sound
GO:0007626	locomotory behavior
GO:0016339	calcium-dependent cell-cell adhesion
GO:0042472	inner ear morphogenesis
GO:0042491	auditory receptor cell differentiation
GO:0048563	post-embryonic organ morphogenesis
GO:0048839	inner ear development
GO:0050953	sensory perception of light stimulus
GO:0060088	auditory receptor cell stereocilium organization

Cellular Component

GO:0001917	photoreceptor inner segment
GO:0005813	centrosome
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0032420	stereocilium
GO:0032426	stereocilium bundle tip
GO:0045202	synapse
GO:0060091	kinocilium