InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cdh23

Summary

InnateDB Gene

IDBG-154608.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cdh23

Gene Name

cadherin 23 (otocadherin)

Synonyms

4930542A03Rik; ahl; ahl1; bob; bus; mdfw; nmf112; nmf181; nmf252; sals; USH1D; v

Species

Mus musculus

Ensembl Gene

ENSMUSG00000012819

Encoded Proteins

IDBP-154610

cadherin 23 (otocadherin)

IDBP-270828

cadherin 23 (otocadherin)

IDBP-270830

cadherin 23 (otocadherin)

IDBP-270832

cadherin 23 (otocadherin)

IDBP-270834

cadherin 23 (otocadherin)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000107736:
This gene is a member of the cadherin superfamily, whose genes encode calcium dependent cell-cell adhesion glycoproteins. The encoded protein is thought to be involved in stereocilia organization and hair bundle formation. The gene is located in a region containing the human deafness loci DFNB12 and USH1D. Usher syndrome 1D and nonsyndromic autosomal recessive deafness DFNB12 are caused by allelic mutations of this cadherin-like gene. Alternative splice variants encoding different isoforms have been described. [provided by RefSeq, Jan 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:60302748-60696490

Strand

Reverse strand

Band

Transcripts

ENSMUST00000073242	ENSMUSP00000072973
ENSMUST00000105464	ENSMUSP00000101104
ENSMUST00000105463	ENSMUSP00000101103
ENSMUST00000105462	ENSMUSP00000101102
ENSMUST00000105461	ENSMUSP00000101101
ENSMUST00000153525
ENSMUST00000151194
ENSMUST00000135638
ENSMUST00000128249
ENSMUST00000156501
ENSMUST00000127312
ENSMUST00000144462
ENSMUST00000124712
ENSMUST00000153149
ENSMUST00000153677
ENSMUST00000123309

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0007155	cell adhesion
GO:0007156	homophilic cell adhesion
GO:0007605	sensory perception of sound
GO:0007626	locomotory behavior
GO:0016339	calcium-dependent cell-cell adhesion
GO:0042472	inner ear morphogenesis
GO:0042491	auditory receptor cell differentiation
GO:0048563	post-embryonic organ morphogenesis
GO:0048839	inner ear development
GO:0050953	sensory perception of light stimulus
GO:0060088	auditory receptor cell stereocilium organization

Cellular Component

GO:0001917	photoreceptor inner segment
GO:0005813	centrosome
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0032420	stereocilium
GO:0032426	stereocilium bundle tip
GO:0045202	synapse
GO:0060091	kinocilium

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000107736

View Gene Order

ENSBTAG00000021497

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.440327

RefSeq

NM_001252635 NM_023370 XM_006513594 XM_006513595 XM_006513596 XM_006513597 XM_006513598 XM_006513599 XM_006513600 XM_006513601 XM_006513603 XM_006513604

OMIM

CCDS

CCDS56704

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas