Version 5.4
Mus musculus Protein: Vps26a
Summary
InnateDB Protein IDBP-270862.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Vps26a
Protein Name vacuolar protein sorting 26 homolog A (yeast)
Synonyms AA407240; HB58; Vps26;
Species Mus musculus
Ensembl Protein ENSMUSP00000101087
InnateDB Gene IDBG-157515 (Vps26a)
Protein Structure
UniProt Annotation
Function Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). {ECO:0000269PubMed:15078902}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:15078902}. Endosome membrane {ECO:0000269PubMed:15078902}; Peripheral membrane protein {ECO:0000269PubMed:15078902}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 8 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 36 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0015031 protein transport
GO:0042147 retrograde transport, endosome to Golgi
Cellular Component
GO:0005768 endosome
GO:0005829 cytosol
GO:0010008 endosome membrane
GO:0031982 vesicle
Protein Structure and Domains
PDB ID MGI:1353654
InterPro IPR028934 Vacuolar protein sorting protein 26 related
PFAM PF03643
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P40336
PhosphoSite PhosphoSite-P40336
TrEMBL
UniProt Splice Variant
Entrez Gene 30930
UniGene Mm.473468
RefSeq NP_598433
MGI ID
MGI Symbol Vps26a
OMIM
CCDS CCDS35921
HPRD
IMGT
EMBL AK028096 AK147989 AK150244 AK151360 AK159783 AK165853 AK167592 AK168213 AK168537 BC007148 S41204
GenPept AAB22718 AAH07148 BAC25745 BAE28271 BAE29408 BAE30335 BAE35367 BAE38415 BAE39650 BAE40171 BAE40415

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca