InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Vps26a

Summary

InnateDB Gene

IDBG-157515.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Vps26a

Gene Name

vacuolar protein sorting 26 homolog A (yeast)

Synonyms

AA407240; HB58; Vps26

Species

Mus musculus

Ensembl Gene

ENSMUSG00000020078

Encoded Proteins

IDBP-157517

vacuolar protein sorting 26 homolog A (yeast)

IDBP-270862

vacuolar protein sorting 26 homolog A (yeast)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000122958:
This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:62454843-62486805

Strand

Reverse strand

Band

Transcripts

ENSMUST00000092473	ENSMUSP00000090130
ENSMUST00000105447	ENSMUSP00000101087

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	8 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	36 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0015031	protein transport
GO:0042147	retrograde transport, endosome to Golgi

Cellular Component

GO:0005768	endosome
GO:0005829	cytosol
GO:0010008	endosome membrane
GO:0031982	vesicle
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome