InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Egr2

Summary

InnateDB Protein

IDBP-270880.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Egr2

Protein Name

early growth response 2

Synonyms

Egr-2; Krox-20; Krox20; NGF1-B; Zfp-25; Zfp-6;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000101078

InnateDB Gene

IDBG-159898 (Egr2)

Protein Structure

UniProt Annotation

Function

Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4. Binds to the promoter region of ERBB2. May play a role in the regulation of hindbrain segmentation, might act in combination with the Hox network to specify odd and even rhombomeres, and might participate in the control of the expression of some of the homeobox containing genes. {ECO:0000269PubMed:1674431, ECO:0000269PubMed:17938205, ECO:0000269PubMed:1969796}.E3 SUMO-protein ligase helping SUMO1 conjugation to its coregulators NAB1 and NAB2, whose sumoylation down-regulates EGR2 own transcriptional activity. {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:17938205}.

Disease Associations

Tissue Specificity

Expressed in mammary tumors (at protein level). Expressed mainly in adult thymus and embryonic nervous system. {ECO:0000269PubMed:17938205}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 64 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	64 [view]
Protein-Protein	10 [view]
Protein-DNA	53 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001102	RNA polymerase II activating transcription factor binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0016874	ligase activity
GO:0031625	ubiquitin protein ligase binding
GO:0044212	transcription regulatory region DNA binding
GO:0046872	metal ion binding
GO:0071837	HMG box domain binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006611	protein export from nucleus
GO:0007611	learning or memory
GO:0007622	rhythmic behavior
GO:0008045	motor neuron axon guidance
GO:0014037	Schwann cell differentiation
GO:0016925	protein sumoylation
GO:0021569	rhombomere 3 development
GO:0021612	facial nerve structural organization
GO:0021660	rhombomere 3 formation
GO:0021666	rhombomere 5 formation
GO:0030278	regulation of ossification
GO:0032868	response to insulin
GO:0035284	brain segmentation
GO:0035914	skeletal muscle cell differentiation
GO:0042552	myelination
GO:0043066	negative regulation of apoptotic process
GO:0045444	fat cell differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048168	regulation of neuronal synaptic plasticity
GO:0071310	cellular response to organic substance
GO:0071320	cellular response to cAMP
GO:0071371	cellular response to gonadotropin stimulus