InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Agpat3

Summary

InnateDB Protein

IDBP-270984.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Agpat3

Protein Name

1-acylglycerol-3-phosphate O-acyltransferase 3

Synonyms

AW061257; AW493985; D10Jhu12e; lpaat3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000101027

InnateDB Gene

IDBG-168869 (Agpat3)

Protein Structure

UniProt Annotation

Function

Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Acts on LPA containing saturated or unsaturated fatty acids C16:0-C20:4 at the sn-1 position using C18:1, C20:4 or C18:2-CoA as the acyl donor. Also acts on lysophosphatidylcholine, lysophosphatidylinositol and lysophosphatidylserine using C18:1 or C20:4-CoA. {ECO:0000269PubMed:15367102}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Nucleus envelope {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed. {ECO:0000269PubMed:15367102}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity
GO:0016746	transferase activity, transferring acyl groups

Biological Process

GO:0008152	metabolic process
GO:0016024	CDP-diacylglycerol biosynthetic process

Cellular Component

GO:0005635	nuclear envelope
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane
GO:0016021	integral component of membrane