InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cirbp

Summary

InnateDB Protein

IDBP-271031.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cirbp

Protein Name

cold inducible RNA binding protein

Synonyms

Cirp; R74941;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000101004

InnateDB Gene

IDBG-173083 (Cirbp)

Protein Structure

UniProt Annotation

Function

Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Promotes assembly of stress granules (SGs), when overexpressed. Seems to play an essential role in cold-induced suppression of cell proliferation. Acts as a translational repressor. Acts as a translational activator. Binds specifically to the 3'-untranslated regions (3'- UTRs) of stress-responsive transcripts RPA2 and TXN. {ECO:0000269PubMed:17967451, ECO:0000269PubMed:9151692}.

Subcellular Localization

Nucleus, nucleoplasm {ECO:0000269PubMed:17967451}. Cytoplasm {ECO:0000269PubMed:17967451}. Note=Translocates from the nucleus to the cytoplasm after exposure to UV radiation (By similarity). Translocates from the nucleus to the cytoplasm into stress granules upon various cytoplasmic stresses, such as osmotic and heat shocks. Its recruitment into stress granules occurs in the absence of TIAR proteins. {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 41 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	41 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003730	mRNA 3'-UTR binding
GO:0030371	translation repressor activity
GO:0070181	SSU rRNA binding

Biological Process

GO:0009409	response to cold
GO:0009411	response to UV
GO:0017148	negative regulation of translation
GO:0034063	stress granule assembly
GO:0045727	positive regulation of translation
GO:0048255	mRNA stabilization