InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Plk5

Summary

InnateDB Protein

IDBP-271061.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Plk5

Protein Name

polo-like kinase 5 (Drosophila)

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000100988

InnateDB Gene

IDBG-173882 (Plk5)

Protein Structure

UniProt Annotation

Function

Inactive serine/threonine-protein kinase that plays a role in cell cycle progression and neuronal differentiation. {ECO:0000269PubMed:20100802, ECO:0000269PubMed:21245385}.

Subcellular Localization

Nucleus, nucleolus {ECO:0000269PubMed:20100802}. Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in the cerebellum, eye and brain cortex (at protein level). Expressed in highly differentiated tissues, such as brain, eyes and ovary. Not detectable in proliferating tissues, such as the colon, spleen and placenta.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0046872	metal ion binding

Biological Process

GO:0002357	defense response to tumor cell
GO:0006468	protein phosphorylation
GO:0006927	transformed cell apoptotic process
GO:0006974	cellular response to DNA damage stimulus
GO:0007049	cell cycle
GO:0008285	negative regulation of cell proliferation
GO:0010976	positive regulation of neuron projection development
GO:0051301	cell division
GO:2000045	regulation of G1/S transition of mitotic cell cycle

Cellular Component

GO:0005730	nucleolus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:3026984

InterPro

IPR000719 Protein kinase domain
IPR000959 POLO box duplicated domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF00659
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt