Version 5.4
Mus musculus Protein: Tcf3
Summary
InnateDB Protein IDBP-271081.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol Tcf3
Protein Name transcription factor 3
Synonyms A1; AA408400; ALF2; AW209082; bHLHb21; E12; E12/E47; E2A; E47; ME2; Pan1; Pan2; TCF-3; Tcfe2a; VDIR;
Species Mus musculus
Ensembl Protein ENSMUSP00000100978
InnateDB Gene IDBG-174161 (Tcf3)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 128 experimentally validated interaction(s) in this database.
They are also associated with 129 interaction(s) predicted by orthology.
Experimentally validated
Total 128 [view]
Protein-Protein 119 [view]
Protein-DNA 8 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 129 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
GO:0043565 sequence-specific DNA binding
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
Biological Process
GO:0001779 natural killer cell differentiation
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0010628 positive regulation of gene expression
GO:0030098 lymphocyte differentiation
GO:0032496 response to lipopolysaccharide
GO:0033077 T cell differentiation in thymus
GO:0033152 immunoglobulin V(D)J recombination
GO:0042493 response to drug
GO:0043966 histone H3 acetylation
GO:0043967 histone H4 acetylation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048468 cell development
GO:0048541 Peyer's patch development
GO:0050821 protein stabilization
Cellular Component
GO:0000788 nuclear nucleosome
GO:0005634 nucleus
GO:0005667 transcription factor complex
Protein Structure and Domains
PDB ID MGI:98510
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
PFAM PF00010
PRINTS
PIRSF
SMART SM00353
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q80Z31
UniProt Splice Variant
Entrez Gene 21423
UniGene Mm.3406
RefSeq
MGI ID
MGI Symbol Tcf3
OMIM
CCDS
HPRD
IMGT
EMBL AB095606 AC152062
GenPept BAC65347

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca