Mus musculus Gene: Tcf3
Summary
InnateDB Gene IDBG-174161.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol Tcf3
Gene Name transcription factor 3
Synonyms A1; AA408400; ALF2; AW209082; bHLHb21; E12; E12/E47; E2A; E47; ME2; Pan1; Pan2; Tcfe2a; VDIR;
Species Mus musculus
Ensembl Gene ENSMUSG00000020167
Encoded Proteins
transcription factor 3
transcription factor 3
transcription factor 3
transcription factor 3
transcription factor 3
transcription factor 3
transcription factor 3
transcription factor 3
transcription factor 3
transcription factor 3
transcription factor 3
transcription factor 3
Protein Structure
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000071564:
This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t(1;19), with PBX1), childhood leukemia (t(19;19), with TFPT) and acute leukemia (t(12;19), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:80409514-80433647
Strand Reverse strand
Band C1
Transcripts
ENSMUST00000020377 ENSMUSP00000020377
ENSMUST00000020379 ENSMUSP00000020379
ENSMUST00000105346 ENSMUSP00000100983
ENSMUST00000105345 ENSMUSP00000100982
ENSMUST00000105344 ENSMUSP00000100981
ENSMUST00000105343 ENSMUSP00000100980
ENSMUST00000105342 ENSMUSP00000100979
ENSMUST00000105341 ENSMUSP00000100978
ENSMUST00000105340 ENSMUSP00000100977
ENSMUST00000105339 ENSMUSP00000100976
ENSMUST00000156990 ENSMUSP00000121172
ENSMUST00000129027
ENSMUST00000127931
ENSMUST00000156244 ENSMUSP00000120303
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 129 experimentally validated interaction(s) in this database.
They are also associated with 132 interaction(s) predicted by orthology.
Experimentally validated
Total 129 [view]
Protein-Protein 120 [view]
Protein-DNA 8 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 132 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0031435 mitogen-activated protein kinase kinase kinase binding
GO:0042803 protein homodimerization activity
GO:0043425 bHLH transcription factor binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
GO:0070491 repressing transcription factor binding
GO:0070644 vitamin D response element binding
GO:0070888 E-box binding
Biological Process
GO:0000080 G1 phase of mitotic cell cycle
GO:0001779 natural killer cell differentiation
GO:0002326 B cell lineage commitment
GO:0006351 transcription, DNA-dependent
GO:0006355 regulation of transcription, DNA-dependent
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0010628 positive regulation of gene expression
GO:0030098 lymphocyte differentiation
GO:0030890 positive regulation of B cell proliferation
GO:0032496 response to lipopolysaccharide
GO:0033077 T cell differentiation in thymus
GO:0033152 immunoglobulin V(D)J recombination
GO:0042493 response to drug
GO:0043966 histone H3 acetylation
GO:0043967 histone H4 acetylation
GO:0045666 positive regulation of neuron differentiation
GO:0045787 positive regulation of cell cycle
GO:0045893 positive regulation of transcription, DNA-dependent
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048468 cell development
GO:0048541 Peyer's patch development
GO:0050821 protein stabilization
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
Cellular Component
GO:0000788 nuclear nucleosome
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
GO:0043234 protein complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
CDO in myogenesis pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
Notch pathway
ID pathway
Wnt pathway
REACTOME
CDO in myogenesis pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Notch-mediated HES/HEY network
Regulation of nuclear SMAD2/3 signaling
p38 signaling mediated by MAPKAP kinases
Cross-References
SwissProt P15806
TrEMBL D3Z037 E9PVV1 E9PVV2 E9PWE2 E9PWE3 E9PWE4 E9PWE5 Q80Z31 Q9CRT1
UniProt Splice Variant
Entrez Gene 21423
UniGene Mm.3406
RefSeq NM_001164147 NM_001164148 NM_001164149 NM_001164150 NM_001164151 NM_001164152 NM_001164153 NM_011548
OMIM
CCDS CCDS24022 CCDS48630 CCDS48631 CCDS48632 CCDS48633 CCDS48634 CCDS48635 CCDS48636
HPRD
IMGT
MGI ID 98510 MGI:98510
MGI Symbol Tcf3
EMBL AB095606 AC152062 AF352579 AK014300 AK017617 AK038738 AK156265 BC006860 BC018260 D16631 D16632 D16633 D16634 D16635 D16636 D16637 D16638 D29919 X17500
GenPept AAH06860 AAH18260 AAK18618 BAA04057 BAA04058 BAA04059 BAA04060 BAA04061 BAA04062 BAA04063 BAA04064 BAA06218 BAB29255 BAB30842 BAC30118 BAC65347 BAE33647 CAA35541
ImmGen Tcf3 (murine)
RNA Seq Atlas 21423