InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tbxa2r

Summary

InnateDB Protein

IDBP-271114.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tbxa2r

Protein Name

thromboxane A2 receptor

Synonyms

TP; TXA2-R;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000100962

InnateDB Gene

IDBG-178084 (Tbxa2r)

Protein Structure

UniProt Annotation

Function

Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C and adenylyl cyclase.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004960	thromboxane receptor activity
GO:0005515	protein binding

Biological Process

GO:0006954	inflammatory response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007584	response to nutrient
GO:0019229	regulation of vasoconstriction
GO:0019932	second-messenger-mediated signaling
GO:0032496	response to lipopolysaccharide
GO:0042493	response to drug
GO:0045766	positive regulation of angiogenesis
GO:0045777	positive regulation of blood pressure
GO:0045907	positive regulation of vasoconstriction
GO:0045987	positive regulation of smooth muscle contraction