Version 5.4
Mus musculus Protein: Tmpo
Summary
InnateDB Protein IDBP-271188.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tmpo
Protein Name thymopoietin
Synonyms 5630400D24Rik; AI195756; AI606875; AW214352; AW547477; LAP2; TP;
Species Mus musculus
Ensembl Protein ENSMUSP00000100930
InnateDB Gene IDBG-185294 (Tmpo)
Protein Structure
UniProt Annotation
Function May help direct the assembly of the nuclear lamina and thereby help maintain the structural organization of the nuclear envelope. Possible receptor for attachment of lamin filaments to the inner nuclear membrane. May be involved in the control of initiation of DNA replication through its interaction with NAKAP95 (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus inner membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Chromosome {ECO:0000250}. Note=Tightly associated with the nuclear lamina. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 42 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 42 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
Cellular Component
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005637 nuclear inner membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:106920
InterPro IPR003887 LEM domain
IPR011015 LEM/LEM-like domain
IPR013146 LEM-like domain
PFAM PF03020
PF08198
PRINTS
PIRSF
SMART SM00540
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q61029
PhosphoSite PhosphoSite-Q61029
TrEMBL Q3TXQ1
UniProt Splice Variant
Entrez Gene 21917
UniGene Mm.409968
RefSeq NP_001073601
MGI ID
MGI Symbol Tmpo
OMIM
CCDS CCDS36032
HPRD
IMGT
EMBL AK150305 AK150515 AK153281 AK159161 AK165851 CH466539 U39074 U39075 U39076 U39077
GenPept AAC52574 AAC52575 AAC52576 AAC52577 BAE29455 BAE29627 BAE31865 BAE34864 BAE38413 EDL21533

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca