|
InnateDB Protein
|
IDBP-271246.6
|
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
|
Gene Symbol
|
Cnot2
|
|
Protein Name
|
CCR4-NOT transcription complex, subunit 2
|
|
Synonyms
|
2600016M12Rik; 2810470K03Rik; AA537049; AA959607; AW557563; C79650;
|
|
Species
|
Mus musculus
|
|
Ensembl Protein
|
ENSMUSP00000100900
|
|
InnateDB Gene
|
IDBG-191316 (Cnot2)
|
|
Protein Structure
|
|
| Function |
Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specificly involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of emryonic stem (ES) cell identity; prevents their differentiation towards extraembryonic trophectoderm lineages. {ECO:0000269PubMed:22367759}.
|
| Subcellular Localization |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000305}.
|
| Disease Associations |
|
| Tissue Specificity |
|
| Comments |
|
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.
|
|
| Predicted by orthology |
| Total |
26 [view]
|
|
|
Molecular Function |
| Accession |
GO Term |
|
GO:0001226
|
RNA polymerase II transcription corepressor binding
|
|
GO:0004535
|
poly(A)-specific ribonuclease activity
|
|
| Biological Process |
|
GO:0000122
|
negative regulation of transcription from RNA polymerase II promoter
|
|
GO:0001829
|
trophectodermal cell differentiation
|
|
GO:0006351
|
transcription, DNA-templated
|
|
GO:0006355
|
regulation of transcription, DNA-templated
|
|
GO:0006417
|
regulation of translation
|
|
GO:0010606
|
positive regulation of cytoplasmic mRNA processing body assembly
|
|
GO:0031047
|
gene silencing by RNA
|
|
GO:0033147
|
negative regulation of intracellular estrogen receptor signaling pathway
|
|
GO:0090503
|
RNA phosphodiester bond hydrolysis, exonucleolytic
|
|
GO:2000036
|
regulation of stem cell maintenance
|
|
| Cellular Component |
|
| PDB ID |
MGI:1919318
|
| InterPro |
IPR007282
NOT2/NOT3/NOT5
|
| PFAM |
PF04153
|
| PRINTS |
|
| PIRSF |
|
| SMART |
|
| TIGRFAMs |
|
| Modification |
|
| SwissProt |
Q8C5L3
|
| PhosphoSite |
PhosphoSite-Q8C5L3
|
| TrEMBL |
|
| UniProt Splice Variant |
|
| Entrez Gene |
72068
|
| UniGene |
|
| RefSeq |
|
| MGI ID |
|
| MGI Symbol |
Cnot2
|
| OMIM |
|
| CCDS |
|
| HPRD |
|
| IMGT |
|
| EMBL |
AK011231
AK078121
AK149767
BC043133
BC063105
BC065171
|
| GenPept |
AAH43133
AAH63105
AAH65171
BAB27481
BAC37134
BAE29072
|
|
|
|
Version 5.4