Version 5.4
Mus musculus Gene: Cnot2
Summary
InnateDB Gene IDBG-191316.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cnot2
Gene Name CCR4-NOT transcription complex, subunit 2
Synonyms 2600016M12Rik; 2810470K03Rik; AA537049; AA959607; AW557563; C79650
Species Mus musculus
Ensembl Gene ENSMUSG00000020166
Encoded Proteins
IDBP-191320
CCR4-NOT transcription complex, subunit 2
IDBP-271242
CCR4-NOT transcription complex, subunit 2
IDBP-271246
CCR4-NOT transcription complex, subunit 2
IDBP-626593
CCR4-NOT transcription complex, subunit 2
IDBP-626597
CCR4-NOT transcription complex, subunit 2
IDBP-626600
CCR4-NOT transcription complex, subunit 2
IDBP-626601
CCR4-NOT transcription complex, subunit 2
IDBP-626605
CCR4-NOT transcription complex, subunit 2
IDBP-626606
CCR4-NOT transcription complex, subunit 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000111596:
This gene encodes a subunit of the multi-component CCR4-NOT complex. The CCR4-NOT complex regulates mRNA synthesis and degradation and is also thought to be involved in mRNA splicing, transport and localization. The encoded protein interacts with histone deacetylases and functions as a repressor of polymerase II transcription. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:116485161-116581511
Strand Reverse strand
Band D2
Transcripts
ENSMUST00000020374 ENSMUSP00000020374
ENSMUST00000105267 ENSMUSP00000100902
ENSMUST00000105265 ENSMUSP00000100900
ENSMUST00000164088 ENSMUSP00000127830
ENSMUST00000169576 ENSMUSP00000130192
ENSMUST00000169921 ENSMUSP00000132152
ENSMUST00000167706 ENSMUSP00000128837
ENSMUST00000169937
ENSMUST00000171214
ENSMUST00000164383
ENSMUST00000166166
ENSMUST00000169507 ENSMUSP00000128720
ENSMUST00000171944
ENSMUST00000165527
ENSMUST00000167644
ENSMUST00000168036 ENSMUSP00000132315
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.
Predicted by orthology
Total 26 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001226 RNA polymerase II transcription corepressor binding
GO:0004535 poly(A)-specific ribonuclease activity
GO:0005515 protein binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001829 trophectodermal cell differentiation
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006417 regulation of translation
GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly
GO:0031047 gene silencing by RNA
GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway
GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic
GO:2000036 regulation of stem cell maintenance
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0030014 CCR4-NOT complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000111596
View Gene Order
ENSBTAG00000003748
Not yet available
Pathways
NETPATH
REACTOME
REACT_244119
Deadenylation of mRNA pathway
REACT_233572
Gene Expression pathway
REACT_235784
Deadenylation-dependent mRNA decay pathway
KEGG
mmu03018
RNA degradation pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_20514
Deadenylation of mRNA pathway
REACT_20639
Deadenylation-dependent mRNA decay pathway
REACT_71
Gene Expression pathway
KEGG
hsa03018
RNA degradation pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001037846 NM_001037847 NM_001037848 NM_028082 XM_006514174 XM_006514175 XM_006514176 XM_006514177 XM_006514178 XM_006514179 XM_006514180 XM_006514181 XM_006514182 XM_006514183 XM_006514184 XM_006514185 XM_006514187 XM_006514189 XM_006514190 XM_006514191
OMIM
CCDS CCDS24185 CCDS36064 CCDS36065
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca