InnateDB Protein
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IDBP-271324.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Cd63
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Protein Name
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CD63 antigen
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Synonyms
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C75951; ME491; Tspan30;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000100862
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InnateDB Gene
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IDBG-198573 (Cd63)
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Protein Structure
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Function |
Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli. {ECO:0000269PubMed:19075008, ECO:0000269PubMed:21803846, ECO:0000269PubMed:21962903, ECO:0000269PubMed:23632027, ECO:0000269PubMed:23945142}.
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Subcellular Localization |
Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Lysosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Endosome, multivesicular body {ECO:0000250}. Melanosome {ECO:0000250}. Note=Also found in Weibel-Palade bodies of endothelial cells. Located in platelet dense granules. Detected in a subset of pre-melanosomes. Detected on intralumenal vesicles (ILVs) within multivesicular bodies (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Ubiquitous. Strongly expressed in kidney. Detected in spleen, bone marrow, peripheral blood mononuclear cells and macrophages.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
15 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:99529
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InterPro |
IPR000301
Tetraspanin
IPR008952
Tetraspanin, EC2 domain
IPR018499
Tetraspanin/Peripherin
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PFAM |
PF00335
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PRINTS |
PR00259
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PIRSF |
PIRSF002419
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P41731
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PhosphoSite |
PhosphoSite-P41731
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TrEMBL |
Q8BT06
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UniProt Splice Variant |
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Entrez Gene |
12512
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UniGene |
Mm.413564
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RefSeq |
NP_001036045
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MGI ID |
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MGI Symbol |
Cd63
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OMIM |
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CCDS |
CCDS24297
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HPRD |
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IMGT |
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EMBL |
AF159427
AK028220
AK146618
AK151702
AK151963
AK152072
AK152372
AK159875
AK163785
AK166543
AK166766
AK170344
BC008108
BC012212
BC083161
CH466578
CT010179
D16432
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GenPept |
AAD43135
AAH08108
AAH12212
AAH83161
BAA03904
BAC25821
BAE27307
BAE30625
BAE30834
BAE30925
BAE31162
BAE35447
BAE37493
BAE38843
BAE39004
BAE41734
CAJ18387
EDL24631
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