Version 5.4
Homo sapiens Protein: TFPI2
Summary
InnateDB Protein IDBP-27155.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TFPI2
Protein Name tissue factor pathway inhibitor 2
Synonyms PP5; REF1; TFPI-2;
Species Homo sapiens
Ensembl Protein ENSP00000222543
InnateDB Gene IDBG-27153 (TFPI2)
Protein Structure
UniProt Annotation
Function May play a role in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, plasmin, factor VIIa/tissue factor and weakly factor Xa. Has no effect on thrombin. {ECO:0000269PubMed:7872799}.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Umbilical vein endothelial cells, liver, placenta, heart, pancreas, and maternal serum at advanced pregnancy.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005201 extracellular matrix structural constituent
GO:0030414 peptidase inhibitor activity
Biological Process
GO:0007596 blood coagulation
GO:0010466 negative regulation of peptidase activity
GO:0010951 negative regulation of endopeptidase activity
Cellular Component
GO:0005576 extracellular region
GO:0005578 proteinaceous extracellular matrix
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR002223 Proteinase inhibitor I2, Kunitz metazoa
IPR008296 Proteinase inhibitor I2, tissue factor pathway inhibitor
PFAM PF00014
PRINTS PR00759
PIRSF PIRSF001620
SMART SM00131
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P48307
PhosphoSite PhosphoSite-
TrEMBL Q8NE89
UniProt Splice Variant
Entrez Gene 7980
UniGene Hs.732432
RefSeq NP_006519
HUGO HGNC:11761
OMIM 600033
CCDS CCDS5632
HPRD 08962
IMGT
EMBL AC002076 AF217542 AK092499 AK313260 AY691946 BC005330 BC034155 CH236949 CH471091 D29992 L27624
GenPept AAA20094 AAH05330 AAH34155 AAK13254 AAS02022 AAU04568 BAA06272 BAC03906 BAG36070 EAL24140 EAW76809 EAW76811

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca