Version 5.4
Homo sapiens Gene: TFPI2
Summary
InnateDB Gene IDBG-27153.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TFPI2
Gene Name tissue factor pathway inhibitor 2
Synonyms PP5; REF1; TFPI-2
Species Homo sapiens
Ensembl Gene ENSG00000105825
Encoded Proteins
IDBP-27155
tissue factor pathway inhibitor 2
IDBP-382019
tissue factor pathway inhibitor 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the Kunitz-type serine proteinase inhibitor family. The protein can inhibit a variety of serine proteases including factor VIIa/tissue factor, factor Xa, plasmin, trypsin, chymotryspin and plasma kallikrein. This gene has been identified as a tumor suppressor gene in several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:93885397-93890991
Strand Reverse strand
Band q21.3
Transcripts
ENST00000222543 ENSP00000222543
ENST00000451238 ENSP00000416370
ENST00000461482
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005201 extracellular matrix structural constituent
GO:0030414 peptidase inhibitor activity
Biological Process
GO:0007596 blood coagulation
GO:0010466 negative regulation of peptidase activity
GO:0010951 negative regulation of endopeptidase activity
Cellular Component
GO:0005576 extracellular region
GO:0005578 proteinaceous extracellular matrix
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029664
View Gene Order
ENSBTAG00000015844
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.438231 Hs.702084 Hs.732212 Hs.732432
RefSeq NM_001271003 NM_001271004 NM_006528
HUGO
OMIM
CCDS CCDS5632
HPRD 08962
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca