InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CDC37

Summary

InnateDB Protein

IDBP-27269.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CDC37

Protein Name

cell division cycle 37 homolog (S. cerevisiae)

Synonyms

P50CDC37;

Species

Homo sapiens

Ensembl Protein

ENSP00000222005

InnateDB Gene

IDBG-27267 (CDC37)

Protein Structure

UniProt Annotation

Function

Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity. {ECO:0000269PubMed:8666233}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:9482106}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 273 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	273 [view]
Protein-Protein	272 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0031072	heat shock protein binding
GO:0031435	mitogen-activated protein kinase kinase kinase binding
GO:0043422	protein kinase B binding
GO:0051082	unfolded protein binding
GO:0051087	chaperone binding
GO:0051879	Hsp90 protein binding

Biological Process

GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0006605	protein targeting
GO:0051726	regulation of cell cycle
GO:0060334	regulation of interferon-gamma-mediated signaling pathway
GO:0060338	regulation of type I interferon-mediated signaling pathway