InnateDB Protein
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IDBP-27307.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PDE4A
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Protein Name
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phosphodiesterase 4A, cAMP-specific
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Synonyms
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DPDE2; PDE4; PDE46;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000293683
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InnateDB Gene
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IDBG-27301 (PDE4A)
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Protein Structure
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Function |
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. {ECO:0000269PubMed:11566027, ECO:0000269PubMed:17727341}.
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Subcellular Localization |
Isoform 1: Cytoplasm, perinuclear region.Isoform 2: Cytoplasm, perinuclear region. Cell projection, ruffle membrane.Isoform 4: Membrane; Peripheral membrane protein. Note=Isoform 4 has propensity for association with membranes.Isoform 6: Cytoplasm, perinuclear region.Isoform 7: Cytoplasm. Membrane. Note=Predominantly cytoplasmic.
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Disease Associations |
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Tissue Specificity |
Isoform 1 is widely expressed. Isoform 2 is abundant in liver, stomach, testis, thyroid and adrenal glands. It is also found in placenta, kidney, pancreas, ovary, uterus, skin, monocytes, mast cells, macrophages, as well as in bronchial smooth muscle. Isoform 6 is expressed at high levels in the heart and small intestine. It is also found in the brain, kidney, spleen, colon, salivary gland, ovary and peripheral blood lymphocytes. Isoform 7 is expressed predominantly in skeletal muscle and brain and at lower levels in the testis. Isoform 7 is expressed in the brain. Found in specific neuronal subpopulations in cortex, spinal cord and cerebellum (at protein level). {ECO:0000269PubMed:11306681, ECO:0000269PubMed:15738310, ECO:0000269PubMed:18095939}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
9
[view]
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Protein-Protein |
8
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR002073
3\'5\'-cyclic nucleotide phosphodiesterase, catalytic domain
IPR003607
HD/PDEase domain
IPR023088
3\'5\'-cyclic nucleotide phosphodiesterase
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PFAM |
PF00233
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PRINTS |
PR00387
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PIRSF |
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SMART |
SM00471
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TIGRFAMs |
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Modification |
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SwissProt |
P27815
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PhosphoSite |
PhosphoSite-P27815
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TrEMBL |
Q86V67
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UniProt Splice Variant |
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Entrez Gene |
5141
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UniGene |
Hs.89901
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RefSeq |
NP_001104778
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HUGO |
HGNC:8780
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OMIM |
600126
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CCDS |
CCDS45962
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HPRD |
02527
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IMGT |
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EMBL |
AC011461
AC011529
AC011548
AF069487
AF069488
AF069489
AF069490
AF069491
AF073745
AY266362
AY593872
AY618547
BC019864
BC038234
CH471106
L20965
M37744
S75213
U18087
U18088
U68532
U97584
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GenPept |
AAA03588
AAA69697
AAA98540
AAB33798
AAC25679
AAC35012
AAC35013
AAC35014
AAC35015
AAC50458
AAC63832
AAD34217
AAH19864
AAH38234
AAP31234
AAT00628
AAU82096
EAW84104
EAW84105
EAW84108
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