InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PDE4A

Summary

InnateDB Gene

IDBG-27301.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDE4A

Gene Name

phosphodiesterase 4A, cAMP-specific

Synonyms

DPDE2; PDE4; PDE46

Species

Homo sapiens

Ensembl Gene

ENSG00000065989

Encoded Proteins

IDBP-27303

phosphodiesterase 4A, cAMP-specific

IDBP-27307

phosphodiesterase 4A, cAMP-specific

IDBP-27313

phosphodiesterase 4A, cAMP-specific

IDBP-370991

phosphodiesterase 4A, cAMP-specific

IDBP-760663

IDBP-761344

IDBP-766209

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:10416773-10469631

Strand

Forward strand

Band

p13.2

Transcripts

ENST00000380702	ENSP00000370078
ENST00000293683	ENSP00000293683
ENST00000344979	ENSP00000341007
ENST00000440014	ENSP00000394754
ENST00000591971	ENSP00000467137
ENST00000586275
ENST00000590407
ENST00000592685	ENSP00000468507
ENST00000589073	ENSP00000465792

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	8 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity
GO:0005515	protein binding
GO:0030552	cAMP binding
GO:0046872	metal ion binding

Biological Process

GO:0006198	cAMP catabolic process
GO:0007165	signal transduction
GO:0007608	sensory perception of smell
GO:0008152	metabolic process
GO:0010738	regulation of protein kinase A signaling
GO:0035690	cellular response to drug
GO:0043949	regulation of cAMP-mediated signaling

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016020	membrane
GO:0032587	ruffle membrane
GO:0048471	perinuclear region of cytoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000032177

View Gene Order

ENSBTAG00000012032

Not yet available

Pathways

NETPATH

REACTOME

REACT_19327

G alpha (s) signalling events pathway

REACT_15334

DARPP-32 events pathway

REACT_15295

Opioid Signalling pathway

REACT_14797

Signaling by GPCR pathway

REACT_111102

Signal Transduction pathway

REACT_19184

GPCR downstream signaling pathway

KEGG

hsa00230

Purine metabolism pathway

INOH

INOH website

Purine nucleotides nucleosides metabolism pathway

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.89901

RefSeq

NM_001111307 NM_001111308 NM_001111309 NM_001243121 NM_006202 XM_005259933

HUGO

OMIM

CCDS

CCDS12238 CCDS45961 CCDS45962 CCDS45963 CCDS58649

HPRD

02527

IMGT

EMBL

GenPept

RNA Seq Atlas