InnateDB Protein
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IDBP-273714.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Mad2l1
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Protein Name
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MAD2 mitotic arrest deficient-like 1 (yeast)
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Synonyms
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AA673185; MAD2;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000112304
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InnateDB Gene
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IDBG-153481 (Mad2l1)
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Protein Structure
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Function |
Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Required for the execution of the mitotic checkpoint which monitors the process of kinetochore- spindle attachment and inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000250}. Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250}. Note=Recruited by MAD1L1 to unattached kinetochores (By similarity). Recruited to the nuclear pore complex by TPR during interphase (By similarity). Recruited to kinetochores in late prometaphase after BUB1, CENPF, BUB1B and CENPE. Kinetochore association requires the presence of NEK2 (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 51 interaction(s) predicted by orthology.
Experimentally validated |
Total |
34
[view]
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Protein-Protein |
34
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
51 [view]
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Molecular Function |
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Biological Process |
GO:0000070
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mitotic sister chromatid segregation
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GO:0007094
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mitotic spindle assembly checkpoint
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GO:0042177
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negative regulation of protein catabolic process
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GO:0043066
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negative regulation of apoptotic process
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GO:0045841
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negative regulation of mitotic metaphase/anaphase transition
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GO:0060564
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negative regulation of mitotic anaphase-promoting complex activity
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GO:0090267
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positive regulation of mitotic cell cycle spindle assembly checkpoint
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Cellular Component |
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PDB ID |
MGI:1860374
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InterPro |
IPR003511
DNA-binding HORMA
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PFAM |
PF02301
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9Z1B5
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PhosphoSite |
PhosphoSite-Q9Z1B5
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TrEMBL |
Q5HZH8
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UniProt Splice Variant |
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Entrez Gene |
56150
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UniGene |
Mm.490363
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RefSeq |
XP_006506469
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MGI ID |
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MGI Symbol |
Mad2l1
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OMIM |
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CCDS |
CCDS20210
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HPRD |
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IMGT |
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EMBL |
AF261919
AK012590
AK082934
BC089012
CH466523
U83902
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GenPept |
AAD09238
AAF69525
AAH89012
BAB28338
BAC38700
EDK98785
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