Version 5.4
Mus musculus Gene: Mad2l1
Summary
InnateDB Gene IDBG-153481.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mad2l1
Gene Name MAD2 mitotic arrest deficient-like 1
Synonyms AA673185; MAD2
Species Mus musculus
Ensembl Gene ENSMUSG00000029910
Encoded Proteins
IDBP-153485
MAD2 mitotic arrest deficient-like 1 (yeast)
IDBP-273714
MAD2 mitotic arrest deficient-like 1 (yeast)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164109:
MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. MAD2L1 is related to the MAD2L2 gene located on chromosome 1. A MAD2 pseudogene has been mapped to chromosome 14. [provided by RefSeq, Jul 2008]
MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. MAD2L1 is related to the MAD2L2 gene located on chromosome 1. A MAD2 pseudogene has been mapped to chromosome 14. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:66535390-66541033
Strand Forward strand
Band C1
Transcripts
ENSMUST00000101343 ENSMUSP00000098897
ENSMUST00000116605 ENSMUSP00000112304
ENSMUST00000125430
ENSMUST00000135411
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 51 interaction(s) predicted by orthology.
Experimentally validated
Total 34 [view]
Protein-Protein 34 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 51 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0000070 mitotic sister chromatid segregation
GO:0007093 mitotic cell cycle checkpoint
GO:0007094 mitotic spindle assembly checkpoint
GO:0042177 negative regulation of protein catabolic process
GO:0043066 negative regulation of apoptotic process
GO:0045841 negative regulation of mitotic metaphase/anaphase transition
GO:0045930 negative regulation of mitotic cell cycle
GO:0060564 negative regulation of mitotic anaphase-promoting complex activity
GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint
Cellular Component
GO:0000775 chromosome, centromeric region
GO:0000776 kinetochore
GO:0000777 condensed chromosome kinetochore
GO:0000922 spindle pole
GO:0005634 nucleus
GO:0005643 nuclear pore
GO:0005829 cytosol
GO:0048471 perinuclear region of cytoplasm
GO:0072686 mitotic spindle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000164109
View Gene Order
ENSBTAG00000035319
Not yet available
Pathways
NETPATH
REACTOME
REACT_249770
Cell Cycle, Mitotic pathway
REACT_222875
APC/C:Cdc20 mediated degradation of mitotic proteins pathway
REACT_207679
Separation of Sister Chromatids pathway
REACT_198961
Resolution of Sister Chromatid Cohesion pathway
REACT_222604
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins pathway
REACT_188804
Cell Cycle pathway
REACT_244364
APC/C-mediated degradation of cell cycle proteins pathway
REACT_241408
M Phase pathway
REACT_256025
Cell Cycle Checkpoints pathway
REACT_246476
Regulation of APC/C activators between G1/S and early anaphase pathway
REACT_254995
Regulation of mitotic cell cycle pathway
REACT_232480
Amplification of signal from the kinetochores pathway
REACT_199403
Mitotic Metaphase and Anaphase pathway
REACT_256756
Mitotic Prometaphase pathway
REACT_248037
Inactivation of APC/C via direct inhibition of the APC/C complex pathway
REACT_234036
Mitotic Spindle Checkpoint pathway
REACT_256672
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal pathway
REACT_202512
Mitotic Anaphase pathway
REACT_263475
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components pathway
KEGG
mmu04110
Cell cycle pathway
mmu04914
Progesterone-mediated oocyte maturation pathway
mmu04114
Oocyte meiosis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_6
KitReceptor pathway
REACTOME
REACT_1072
Inactivation of APC/C via direct inhibition of the APC/C complex pathway
REACT_1041
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components pathway
REACT_491
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal pathway
REACT_6781
APC/C:Cdc20 mediated degradation of mitotic proteins pathway
REACT_6837
Regulation of APC/C activators between G1/S and early anaphase pathway
REACT_150425
Resolution of Sister Chromatid Cohesion pathway
REACT_682
Mitotic Prometaphase pathway
REACT_150471
Separation of Sister Chromatids pathway
REACT_6828
APC/C-mediated degradation of cell cycle proteins pathway
REACT_6954
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins pathway
REACT_21279
Regulation of mitotic cell cycle pathway
REACT_115566
Cell Cycle pathway
REACT_2137
Mitotic Spindle Checkpoint pathway
REACT_910
M Phase pathway
REACT_1275
Mitotic Anaphase pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_795
Amplification of signal from the kinetochores pathway
REACT_1538
Cell Cycle Checkpoints pathway
REACT_150314
Mitotic Metaphase and Anaphase pathway
KEGG
hsa04110
Cell cycle pathway
hsa04914
Progesterone-mediated oocyte maturation pathway
hsa04114
Oocyte meiosis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.290830 Mm.489653 Mm.490363
RefSeq NM_019499 XM_006506406 XM_006542949
OMIM
CCDS CCDS20210
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca