InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Brms1

Summary

InnateDB Protein

IDBP-273808.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Brms1

Protein Name

breast cancer metastasis-suppressor 1

Synonyms

AV003220; AW554636;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000112266

InnateDB Gene

IDBG-273806 (Brms1)

Protein Structure

UniProt Annotation

Function

Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down- regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Predominantly nuclear. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	28 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006915	apoptotic process
GO:0009987	cellular process
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0045892	negative regulation of transcription, DNA-templated
GO:0090312	positive regulation of protein deacetylation
GO:2000210	positive regulation of anoikis