Version 5.4
Mus musculus Gene: Brms1
Summary
InnateDB Gene IDBG-273806.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Brms1
Gene Name breast cancer metastasis-suppressor 1
Synonyms AV003220; AW554636
Species Mus musculus
Ensembl Gene ENSMUSG00000080268
Encoded Proteins
IDBP-273808
breast cancer metastasis-suppressor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000174744:
This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines. The protein encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:5041404-5049917
Strand Forward strand
Band A
Transcripts
ENSMUST00000116567 ENSMUSP00000112266
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 28 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006915 apoptotic process
GO:0009987 cellular process
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0045892 negative regulation of transcription, DNA-templated
GO:0090312 positive regulation of protein deacetylation
GO:2000210 positive regulation of anoikis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000174744
View Gene Order
ENSBTAG00000017689
Not yet available
Pathways
NETPATH
REACTOME
REACT_218274
Chromatin organization pathway
REACT_202766
Chromatin modifying enzymes pathway
REACT_257106
HDACs deacetylate histones pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_228222
HDACs deacetylate histones pathway
REACT_172623
Chromatin organization pathway
REACT_172633
Chromatin modifying enzymes pathway
REACT_207632
Chromatin organization pathway
REACT_248114
HDACs deacetylate histones pathway
REACT_227044
Chromatin modifying enzymes pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q99N20
TrEMBL Q547N0
UniProt Splice Variant
Entrez Gene 107392
UniGene
RefSeq NM_134155 XM_006531623
OMIM
CCDS CCDS50355
HPRD
IMGT
MGI ID MGI:2388804
MGI Symbol Brms1
EMBL AF233580 AF368292 AF467879 AF467880 AF467881 AF467882 AF467884 AF467885 BC016108 CH466612
GenPept AAH16108 AAK15007 AAK51553 AAL76070 AAL76071 AAL76072 AAL76073 AAL76075 AAL76076 EDL33091 EDL33093
RNA Seq Atlas 107392

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca