InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ASAP2

Summary

InnateDB Protein

IDBP-27383.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ASAP2

Protein Name

ArfGAP with SH3 domain, ankyrin repeat and PH domain 2

Synonyms

AMAP2; CENTB3; DDEF2; PAG3; PAP; Pap-alpha; SHAG1;

Species

Homo sapiens

Ensembl Protein

ENSP00000281419

InnateDB Gene

IDBG-27381 (ASAP2)

Protein Structure

UniProt Annotation

Function

Activates the small GTPases ARF1, ARF5 and ARF6. Regulates the formation of post-Golgi vesicles and modulates constitutive secretion. Modulates phagocytosis mediated by Fc gamma receptor and ARF6. Modulates PXN recruitment to focal contacts and cell migration. {ECO:0000269PubMed:10022920, ECO:0000269PubMed:10749932, ECO:0000269PubMed:11304556}.

Subcellular Localization

Cytoplasm. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Note=Colocalizes with F-actin and ARF6 in phagocytic cups.

Disease Associations

Tissue Specificity

Detected in heart, brain, placenta, kidney, monocytes and pancreas. {ECO:0000269PubMed:10022920}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	20 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008047	enzyme activator activity
GO:0008060	ARF GTPase activator activity
GO:0008270	zinc ion binding

Biological Process

GO:0032312	regulation of ARF GTPase activity
GO:0043085	positive regulation of catalytic activity
GO:0043547	positive regulation of GTPase activity

Cellular Component

GO:0005886	plasma membrane
GO:0032580	Golgi cisterna membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001164 Arf GTPase activating protein
IPR001452 SH3 domain
IPR001849 Pleckstrin homology domain
IPR002110 Ankyrin repeat
IPR011511 Variant SH3 domain
IPR020683 Ankyrin repeat-containing domain

PFAM