InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nck1

Summary

InnateDB Protein

IDBP-273916.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nck1

Protein Name

non-catalytic region of tyrosine kinase adaptor protein 1

Synonyms

6330586M15Rik; D230010O13Rik; Nck; Nck-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000112221

InnateDB Gene

IDBG-193200 (Nck1)

Protein Structure

UniProt Annotation

Function

Adapter protein which associates with tyrosine- phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Nucleus {ECO:0000250}. Note=Mostly cytoplasmic, but shuttles between the cytoplasm and the nucleus. Import into the nucleus requires interaction with SOCS7. Predominantly nuclear following genotoxic stresses, such as UV irradiation, hydroxyurea or mitomycin C treatments (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 209 interaction(s) predicted by orthology.

Experimentally validated
Total	29 [view]
Protein-Protein	29 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	209 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004860	protein kinase inhibitor activity
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0019904	protein domain specific binding
GO:0030971	receptor tyrosine kinase binding

Biological Process

GO:0006417	regulation of translation
GO:0006469	negative regulation of protein kinase activity
GO:0007015	actin filament organization
GO:0016477	cell migration
GO:0030032	lamellipodium assembly
GO:0030838	positive regulation of actin filament polymerization
GO:0042102	positive regulation of T cell proliferation
GO:0042110	T cell activation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051707	response to other organism
GO:0060548	negative regulation of cell death