Version 5.4
Mus musculus Protein: Wbp11
Summary
InnateDB Protein IDBP-273936.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Wbp11
Protein Name WW domain binding protein 11
Synonyms 2510026P17Rik; D6Wsu113e; Npwbp; SIPP1;
Species Mus musculus
Ensembl Protein ENSMUSP00000112213
InnateDB Gene IDBG-195017 (Wbp11)
Protein Structure
UniProt Annotation
Function Activates pre-mRNA splicing. May inhibit PP1 phosphatase activity. {ECO:0000269PubMed:14640981, ECO:0000269PubMed:16162498}.
Subcellular Localization Nucleus. Cytoplasm. Note=Predominantly located in the nucleus with granular heterogeneous distribution. Excluded from nucleoli in interphase cells, distributed throughout cytoplasm in dividing cells. Colocalized with SC35 and U2B in the nucleus. In the cytoplasm, associates with the intermediate filament protein vimentin.
Disease Associations
Tissue Specificity Ubiquitously expressed, with highest levels in testis. {ECO:0000269PubMed:14640981}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 29 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008599 protein phosphatase type 1 regulator activity
GO:0044822 poly(A) RNA binding
GO:0050699 WW domain binding
Biological Process
GO:0006364 rRNA processing
GO:0006396 RNA processing
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0050790 regulation of catalytic activity
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016607 nuclear speck
Protein Structure and Domains
PDB ID MGI:1891823
InterPro IPR019007 WW domain binding protein 11
PFAM PF09429
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q923D5
PhosphoSite PhosphoSite-Q923D5
TrEMBL
UniProt Splice Variant
Entrez Gene 60321
UniGene Mm.412991
RefSeq NP_068360
MGI ID
MGI Symbol Wbp11
OMIM
CCDS CCDS20655
HPRD
IMGT
EMBL AF071186 AK031678 AK041079 AK144968 BC006600 BC021823
GenPept AAC34812 AAH06600 AAH21823 BAC27508 BAC30812 BAE26160

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca