InnateDB Protein
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IDBP-274033.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Pabpn1
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Protein Name
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poly(A) binding protein, nuclear 1
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000112177
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InnateDB Gene
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IDBG-162347 (Pabpn1)
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Protein Structure
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Function |
Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product. Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length. Increases the affinity of poly(A) polymerase for RNA. Is also present at various stages of mRNA metabolism including nucleocytoplasmic trafficking and nonsense-mediated decay (NMD) of mRNA. Cooperates with SKIP to synergistically activate E-box-mediated transcription through MYOD1 and may regulate the expression of muscle-specific genes. Binds to poly(A) and to poly(G) with high affinity. May protect the poly(A) tail from degradation (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Shuttles between the nucleus and the cytoplasm but predominantly found in the nucleus. Its nuclear import may involve the nucleocytoplasmic transport receptor transportin and a RAN-GTP-sensitive import mechanism. It is exported to the cytoplasm by a carrier-mediated pathway that is independent of mRNA traffic. Nucleus; nuclear speckle (By similarity). Colocalizes with SKIP and poly(A) RNA in nuclear speckles (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Ubiquitous. {ECO:0000269PubMed:9434149}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
5
[view]
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Protein-Protein |
5
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1859158
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InterPro |
IPR000504
RNA recognition motif domain
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PFAM |
PF00076
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PRINTS |
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PIRSF |
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SMART |
SM00360
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TIGRFAMs |
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Modification |
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SwissProt |
Q8CCS6
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PhosphoSite |
PhosphoSite-Q8CCS6
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TrEMBL |
G3UWY6
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UniProt Splice Variant |
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Entrez Gene |
54196
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UniGene |
Mm.7723
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RefSeq |
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MGI ID |
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MGI Symbol |
Pabpn1
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AC116591
AK032172
BC055866
U93050
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GenPept |
AAC00210
AAH55866
BAC27741
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