InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cyth3

Summary

InnateDB Protein

IDBP-274086.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cyth3

Protein Name

cytohesin 3

Synonyms

AI648983; ARNO3; CLM3; Grp1; Pscd3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000112157

InnateDB Gene

IDBG-207822 (Cyth3)

Protein Structure

UniProt Annotation

Function

Promotes guanine-nucleotide exchange on ARF1. Promotes the activation of ARF factors through replacement of GDP with GTP. {ECO:0000269PubMed:18042453}.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000250}. Cell membrane {ECO:0000269PubMed:18042453}; Peripheral membrane protein {ECO:0000269PubMed:18042453}. Note=Translocates from the cytosol to membranes enriched in phosphatidylinositol 3,4,5- trisphosphate.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005086	ARF guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding

Biological Process

GO:0032012	regulation of ARF protein signal transduction
GO:0043087	regulation of GTPase activity
GO:0045785	positive regulation of cell adhesion
GO:0048193	Golgi vesicle transport
GO:0090162	establishment of epithelial cell polarity