InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cyth3

Summary

InnateDB Gene

IDBG-207822.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cyth3

Gene Name

cytohesin 3

Synonyms

AI648983; ARNO3; CLM3; Grp1; Pscd3

Species

Mus musculus

Ensembl Gene

ENSMUSG00000018001

Encoded Proteins

IDBP-259649

cytohesin 3

IDBP-274086

cytohesin 3

IDBP-543015

cytohesin 3

IDBP-725173

IDBP-725003

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000008256:
This gene encodes a member of the PSCD (pleckstrin homology, Sec7 and coiled-coil domains) family. PSCD family members have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This encoded protein is involved in the control of Golgi structure and function, and it may have a physiological role in regulating ADP-ribosylation factor protein 6 (ARF) functions, in addition to acting on ARF1. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:143622447-143710250

Strand

Forward strand

Band

Transcripts

ENSMUST00000110727	ENSMUSP00000106355
ENSMUST00000116456	ENSMUSP00000112157
ENSMUST00000131436	ENSMUSP00000118290
ENSMUST00000177196	ENSMUSP00000135548
ENSMUST00000177281	ENSMUSP00000135287

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005086	ARF guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding

Biological Process

GO:0032012	regulation of ARF protein signal transduction
GO:0043087	regulation of GTPase activity
GO:0045785	positive regulation of cell adhesion
GO:0048193	Golgi vesicle transport
GO:0090162	establishment of epithelial cell polarity

Cellular Component

GO:0001726	ruffle
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000008256

View Gene Order

ENSBTAG00000007384

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu04144

Endocytosis pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa04144

Endocytosis pathway

INOH

PID NCI

pi3kcipathway

Class I PI3K signaling events

arf6_pathway

Arf6 signaling events

Cross-References

SwissProt

TrEMBL

H3BK81

UniProt Splice Variant

Entrez Gene

19159

UniGene

Mm.281003 Mm.398925

RefSeq

NM_001163548 NM_011182 XM_006504665 XM_006504666

OMIM

CCDS

CCDS19845 CCDS51691

HPRD

IMGT

MGI ID

MGI:1335107

MGI Symbol

Cyth3

EMBL

AC136746 AC163995

GenPept

RNA Seq Atlas

19159