Version 5.4
Mus musculus Protein: Slc12a4
Summary
InnateDB Protein IDBP-274148.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Slc12a4
Protein Name solute carrier family 12, member 4
Synonyms AW546649; KCC1; RBCKCC1;
Species Mus musculus
Ensembl Protein ENSMUSP00000112130
InnateDB Gene IDBG-189241 (Slc12a4)
Protein Structure
UniProt Annotation
Function Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells. May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia.
Subcellular Localization Membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity Detected in embryo, adult heart, erythrocytes, brain, kidney, stomach, ovary, testis and liver.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0015377 cation:chloride symporter activity
GO:0015379 potassium:chloride symporter activity
GO:0019901 protein kinase binding
Biological Process
GO:0006810 transport
GO:0006811 ion transport
GO:0006813 potassium ion transport
GO:0055085 transmembrane transport
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005765 lysosomal membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1309465
InterPro IPR000076 K-Cl co-transporter
IPR000622 K/Cl co-transporter, type 1
IPR004841 Amino acid permease/ SLC12A domain
IPR004842 Na/K/Cl co-transporter superfamily
IPR018491 K/Cl co-transporter, type 1/type 3
PFAM PF00324
PF03522
PRINTS PR01081
PR01082
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9JIS8
PhosphoSite PhosphoSite-Q9JIS8
TrEMBL Q9QY75
UniProt Splice Variant
Entrez Gene 20498
UniGene Mm.292447
RefSeq NP_033221
MGI ID
MGI Symbol Slc12a4
OMIM
CCDS CCDS22623
HPRD
IMGT
EMBL AF047339 AF116526 AF121118 AF121128 AF191023 AH009673 AK159274 AK159483 AK165874 CH466525
GenPept AAC32816 AAF00978 AAF01138 AAF02444 AAF91090 AAF91094 BAE34953 BAE35120 BAE38430 EDL11336

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca