Mus musculus Gene: Slc12a4
Summary
InnateDB Gene IDBG-189241.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Slc12a4
Gene Name solute carrier family 12, member 4
Synonyms AW546649; KCC1; RBCKCC1
Species Mus musculus
Ensembl Gene ENSMUSG00000017765
Encoded Proteins
solute carrier family 12, member 4
solute carrier family 12, member 4
solute carrier family 12, member 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000124067:
This gene encodes a member of the SLC12A transporter family. The encoded protein mediates the coupled movement of potassium and chloride ions across the plasma membrane. This gene is expressed ubiquitously. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:105943590-105966115
Strand Reverse strand
Band D3
Transcripts
ENSMUST00000034370 ENSMUSP00000034370
ENSMUST00000116429 ENSMUSP00000112130
ENSMUST00000141326
ENSMUST00000132231 ENSMUSP00000121018
ENSMUST00000143381
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0015377 cation:chloride symporter activity
GO:0015379 potassium:chloride symporter activity
GO:0019901 protein kinase binding
Biological Process
GO:0006810 transport
GO:0006811 ion transport
GO:0006813 potassium ion transport
GO:0055085 transmembrane transport
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005765 lysosomal membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
SLC-mediated transmembrane transport pathway
Transport of inorganic cations/anions and amino acids/oligopeptides pathway
Transmembrane transport of small molecules pathway
Cation-coupled Chloride cotransporters pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Cation-coupled Chloride cotransporters pathway
Transport of inorganic cations/anions and amino acids/oligopeptides pathway
Transmembrane transport of small molecules pathway
SLC-mediated transmembrane transport pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q9JIS8
TrEMBL Q3TWZ6 Q9QY65 Q9QY75
UniProt Splice Variant
Entrez Gene 20498
UniGene Mm.292447
RefSeq NM_009195 XM_006530792 NM_001253804
OMIM
CCDS CCDS22623 CCDS57642
HPRD
IMGT
MGI ID MGI:1309465
MGI Symbol Slc12a4
EMBL AF047339 AF116526 AF121118 AF121128 AF191023 AH009673 AK159274 AK159483 AK165874 CH466525
GenPept AAC32816 AAF00978 AAF01138 AAF02444 AAF91090 AAF91094 BAE34953 BAE35120 BAE38430 EDL11336
RNA Seq Atlas 20498