InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Trmt5

Summary

InnateDB Protein

IDBP-274170.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Trmt5

Protein Name

TRM5 tRNA methyltransferase 5 homolog (S. cerevisiae)

Synonyms

2610027O18Rik; mKIAA1393;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000112121

InnateDB Gene

IDBG-148296 (Trmt5)

Protein Structure

UniProt Annotation

Function

Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding. {ECO:0000255HAMAP- Rule:MF_03152}.

Subcellular Localization

Mitochondrion matrix {ECO:0000255HAMAP- Rule:MF_03152}. Nucleus {ECO:0000255HAMAP-Rule:MF_03152}. Cytoplasm {ECO:0000255HAMAP-Rule:MF_03152}. Note=Predominantly in the mitochondria and in the nucleus. {ECO:0000255HAMAP- Rule:MF_03152}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0008168	methyltransferase activity
GO:0016740	transferase activity
GO:0052906	tRNA (guanine(37)-N(1))-methyltransferase activity

Biological Process

GO:0001510	RNA methylation
GO:0008150	biological_process
GO:0009452	7-methylguanosine RNA capping
GO:0030488	tRNA methylation

Cellular Component

GO:0005575	cellular_component
GO:0005634	nucleus
GO:0005759	mitochondrial matrix

Protein Structure and Domains

PDB ID

MGI:1923607

InterPro

IPR003402 tRNA transferase Trm5/Tyw2
IPR019012 RNA cap guanine-N2 methyltransferase
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like

PFAM

PF02475
PF09445

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9D0C4

PhosphoSite