InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MAP1B

Summary

InnateDB Protein

IDBP-27542.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAP1B

Protein Name

microtubule-associated protein 1B

Synonyms

FUTSCH; MAP5; PPP1R102;

Species

Homo sapiens

Ensembl Protein

ENSP00000296755

InnateDB Gene

IDBG-27538 (MAP1B)

Protein Structure

UniProt Annotation

Function

Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B may play a role in the cytoskeletal changes that accompany neurite extension. Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269PubMed:18195017}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000269PubMed:18195017}. Cytoplasm {ECO:0000269PubMed:18195017}. Cell junction, synapse {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Note=Colocalizes with DAPK1 in the microtubules and cortical actin fibers. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 61 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	61 [view]
Protein-Protein	59 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005198	structural molecule activity
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0016787	hydrolase activity

Biological Process

GO:0001578	microtubule bundle formation
GO:0007409	axonogenesis
GO:0008152	metabolic process
GO:0009987	cellular process
GO:0016358	dendrite development
GO:0032387	negative regulation of intracellular transport
GO:0045773	positive regulation of axon extension
GO:0047497	mitochondrion transport along microtubule
GO:0048675	axon extension
GO:0061162	establishment of monopolar cell polarity

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005874	microtubule
GO:0005875	microtubule associated complex
GO:0005886	plasma membrane
GO:0030054	cell junction
GO:0043197	dendritic spine
GO:0045202	synapse