InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MAP1B

Summary

InnateDB Gene

IDBG-27538.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAP1B

Gene Name

microtubule-associated protein 1B

Synonyms

FUTSCH; MAP5; PPP1R102

Species

Homo sapiens

Ensembl Gene

ENSG00000131711

Encoded Proteins

IDBP-27542

microtubule-associated protein 1B

IDBP-478405

microtubule-associated protein 1B

IDBP-479454

microtubule-associated protein 1B

IDBP-484444

microtubule-associated protein 1B

IDBP-484097

microtubule-associated protein 1B

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1B heavy chain and LC1 light chain. Gene knockout studies of the mouse microtubule-associated protein 1B gene suggested an important role in development and function of the nervous system. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:72107234-72209570

Strand

Forward strand

Band

q13.2

Transcripts

ENST00000296755	ENSP00000296755
ENST00000512974	ENSP00000426312
ENST00000504183
ENST00000513526	ENSP00000427194
ENST00000511641	ENSP00000423444
ENST00000504492	ENSP00000423416

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 61 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	61 [view]
Protein-Protein	59 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005198	structural molecule activity
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0016787	hydrolase activity

Biological Process

GO:0000226	microtubule cytoskeleton organization
GO:0001578	microtubule bundle formation
GO:0007409	axonogenesis
GO:0008152	metabolic process
GO:0009987	cellular process
GO:0016358	dendrite development
GO:0032387	negative regulation of intracellular transport
GO:0045773	positive regulation of axon extension
GO:0047497	mitochondrion transport along microtubule
GO:0048675	axon extension
GO:0061162	establishment of monopolar cell polarity

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005874	microtubule
GO:0005875	microtubule associated complex
GO:0005886	plasma membrane
GO:0030054	cell junction
GO:0043197	dendritic spine
GO:0045202	synapse

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000052727

View Gene Order

ENSBTAG00000001961

Not yet available

Pathways

NETPATH

REACTOME

KEGG

INOH

PID NCI

reelinpathway

Reelin signaling pathway

netrin_pathway

Netrin-mediated signaling events

lis1pathway

Lissencephaly gene (LIS1) in neuronal migration and development

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.335079 Hs.601194 Hs.617565 Hs.620747 Hs.718766

RefSeq

NM_005909 XM_005248507

HUGO

OMIM

CCDS

CCDS4012

HPRD

01139

IMGT

EMBL

GenPept

RNA Seq Atlas