InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: STX4

Summary

InnateDB Protein

IDBP-27567.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

STX4

Protein Name

syntaxin 4

Synonyms

p35-2; STX4A;

Species

Homo sapiens

Ensembl Protein

ENSP00000317714

InnateDB Gene

IDBG-27565 (STX4)

Protein Structure

UniProt Annotation

Function

Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity). May also play a role in docking of synaptic vesicles at presynaptic active zones. {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000305}; Single-pass type IV membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed in neutrophils and neutrophil- differentiated HL-60 cells. Expression in neutrophils increases with differentiation. {ECO:0000269PubMed:10080545}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	43 [view]
Protein-Protein	43 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000149	SNARE binding
GO:0005484	SNAP receptor activity
GO:0005515	protein binding

Biological Process

GO:0006836	neurotransmitter transport
GO:0006886	intracellular protein transport
GO:0006892	post-Golgi vesicle-mediated transport
GO:0007596	blood coagulation
GO:0016192	vesicle-mediated transport
GO:0030168	platelet activation
GO:0035493	SNARE complex assembly
GO:0061024	membrane organization

Cellular Component

GO:0005737	cytoplasm
GO:0005773	vacuole
GO:0005802	trans-Golgi network
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0031201	SNARE complex
GO:0035749	myelin sheath adaxonal region
GO:0042581	specific granule
GO:0043219	lateral loop
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome