Version 5.4
Homo sapiens Protein: COPS4
Summary
InnateDB Protein IDBP-27577.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol COPS4
Protein Name COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000264389
InnateDB Gene IDBG-27575 (COPS4)
Protein Structure
UniProt Annotation
Function Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. Also involved in the deneddylation of non-cullin subunits such as STON2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1, IRF8/ICSBP and SNAPIN, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. {ECO:0000269PubMed:11285227, ECO:0000269PubMed:11337588, ECO:0000269PubMed:12628923, ECO:0000269PubMed:12732143, ECO:0000269PubMed:21102408, ECO:0000269PubMed:9535219}.
Subcellular Localization Cytoplasm. Nucleus. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 110 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 110 [view]
Protein-Protein 110 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000338 protein deneddylation
GO:0010388 cullin deneddylation
Cellular Component
GO:0005634 nucleus
GO:0008021 synaptic vesicle
GO:0008180 COP9 signalosome
GO:0030054 cell junction
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000717 Proteasome component (PCI) domain
PFAM PF01399
PRINTS
PIRSF
SMART SM00088
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BT78
PhosphoSite PhosphoSite-Q9BT78
TrEMBL
UniProt Splice Variant
Entrez Gene 51138
UniGene Hs.684069
RefSeq NP_057213
HUGO HGNC:16702
OMIM
CCDS CCDS3600
HPRD 09888
IMGT
EMBL AC021105 AC073840 AC108473 AF100757 AK001210 AK024005 AK094238 BC004302 BC009292 BC093007 CH471057
GenPept AAD43021 AAH04302 AAH09292 AAH93007 BAA91555 BAG51250 BAG52847 EAX05921 EAX05922

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca