InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PON1

Summary

InnateDB Protein

IDBP-27669.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PON1

Protein Name

paraoxonase 1

Synonyms

ESA; MVCD5; PON;

Species

Homo sapiens

Ensembl Protein

ENSP00000222381

InnateDB Gene

IDBG-27667 (PON1)

Protein Structure

UniProt Annotation

Function

Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation. {ECO:0000269PubMed:10479665, ECO:0000269PubMed:15772423}.

Subcellular Localization

Secreted, extracellular space.

Disease Associations

Microvascular complications of diabetes 5 (MVCD5) [MIM:612633]: Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end- stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. Homozygosity for the Leu-55 allele is strongly associated with the development of retinal disease in diabetic patients.

Tissue Specificity

Plasma, associated with HDL (at protein level). Expressed in liver, but not in heart, brain, placenta, lung, skeletal muscle, kidney or pancreas. {ECO:0000269PubMed:8292612, ECO:0000269PubMed:8382160}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	3 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004063	aryldialkylphosphatase activity
GO:0004064	arylesterase activity
GO:0005509	calcium ion binding
GO:0005543	phospholipid binding
GO:0016844	strictosidine synthase activity
GO:0042803	protein homodimerization activity

Biological Process

GO:0006629	lipid metabolic process
GO:0009058	biosynthetic process
GO:0009605	response to external stimulus
GO:0009636	response to toxic substance
GO:0010875	positive regulation of cholesterol efflux
GO:0016311	dephosphorylation
GO:0019439	aromatic compound catabolic process
GO:0031667	response to nutrient levels
GO:0032411	positive regulation of transporter activity
GO:0046395	carboxylic acid catabolic process
GO:0046434	organophosphate catabolic process
GO:0046470	phosphatidylcholine metabolic process
GO:0051099	positive regulation of binding
GO:0070542	response to fatty acid
GO:1902617	response to fluoride

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0034364	high-density lipoprotein particle
GO:0034366	spherical high-density lipoprotein particle
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle