InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PON1

Summary

InnateDB Gene

IDBG-27667.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PON1

Gene Name

paraoxonase 1

Synonyms

ESA; MVCD5; PON

Species

Homo sapiens

Ensembl Gene

ENSG00000005421

Encoded Proteins

IDBP-27669

paraoxonase 1

IDBP-382238

paraoxonase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The enzyme encoded by this gene is an arylesterase that mainly hydrolyzes paroxon to produce p-nitrophenol. Paroxon is an organophosphorus anticholinesterase compound that is produced in vivo by oxidation of the insecticide parathion. Polymorphisms in this gene are a risk factor in coronary artery disease. The gene is found in a cluster of three related paraoxonase genes at 7q21.3. [provided by RefSeq, Oct 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:95297676-95324707

Strand

Reverse strand

Band

q21.3

Transcripts

ENST00000222381	ENSP00000222381
ENST00000433729	ENSP00000407359
ENST00000462594
ENST00000470502

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	3 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004063	aryldialkylphosphatase activity
GO:0004064	arylesterase activity
GO:0005509	calcium ion binding
GO:0005543	phospholipid binding
GO:0016844	strictosidine synthase activity
GO:0042803	protein homodimerization activity

Biological Process

GO:0006629	lipid metabolic process
GO:0009058	biosynthetic process
GO:0009605	response to external stimulus
GO:0009636	response to toxic substance
GO:0010875	positive regulation of cholesterol efflux
GO:0016311	dephosphorylation
GO:0019439	aromatic compound catabolic process
GO:0031667	response to nutrient levels
GO:0032411	positive regulation of transporter activity
GO:0046395	carboxylic acid catabolic process
GO:0046434	organophosphate catabolic process
GO:0046470	phosphatidylcholine metabolic process
GO:0051099	positive regulation of binding
GO:0070542	response to fatty acid
GO:1902617	response to fluoride

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0034364	high-density lipoprotein particle
GO:0034366	spherical high-density lipoprotein particle
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000002588

View Gene Order

ENSBTAG00000015654

Not yet available

Cross-References

SwissProt

P27169

TrEMBL

F8WF42

UniProt Splice Variant

Entrez Gene

5444

UniGene

Hs.370995 Hs.611732

RefSeq

NM_000446

HUGO

HGNC:9204

OMIM

168820

CCDS

CCDS5638

HPRD

IMGT

EMBL

AC004022 AC005021 AF539592 AK314027 BC074719 CH236949 CH471091 D84371 M63012 M63013 M63014 S56546 S56548 S56555 S64615 S64696 U53784 U55877 U55878 U55879 U55880 U55881 U55882 U55883 U55885 Z70723

GenPept

AAA60142 AAA60143 AAA97957 AAB25717 AAB27714 AAB27899 AAB41835 AAB59538 AAC35293 AAH74719 AAM97935 BAA12327 BAG36737 CAA94728 EAL24133 EAW76771

RNA Seq Atlas

5444