Version 5.4
Homo sapiens Protein: ATG4D
Summary
InnateDB Protein IDBP-27680.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ATG4D
Protein Name ATG4 autophagy related 4 homolog D (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000311318
InnateDB Gene IDBG-27678 (ATG4D)
Protein Structure
UniProt Annotation
Function Cysteine protease ATG4D: Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.Cysteine protease ATG4D, mitochondrial: Plays a role as an autophagy regulator that links mitochondrial dysfunction with apoptosis. The mitochondrial import of ATG4D during cellular stress and differentiation may play important roles in the regulation of mitochondrial physiology, ROS, mitophagy and cell viability.
Subcellular Localization Cysteine protease ATG4D: Cytoplasm.Cysteine protease ATG4D, mitochondrial: Cytoplasm. Mitochondrion matrix. Note=Imported into mitochondrial matrix after cleavage by CASP3 during oxidative stress and cell death.
Disease Associations
Tissue Specificity Mainly expressed in skeletal muscle and, to a lower extent, in testis. {ECO:0000269PubMed:12446702}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0006914 autophagy
GO:0006915 apoptotic process
GO:0015031 protein transport
Cellular Component
GO:0005737 cytoplasm
GO:0005759 mitochondrial matrix
Protein Structure and Domains
PDB ID
InterPro IPR005078 Peptidase C54
PFAM PF03416
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q86TL0
PhosphoSite PhosphoSite-Q86TL0
TrEMBL Q969K0
UniProt Splice Variant
Entrez Gene 84971
UniGene Hs.512799
RefSeq NP_116274
HUGO HGNC:20789
OMIM 611340
CCDS CCDS12241
HPRD 07005
IMGT
EMBL AC011461 AJ312332 BC007639 BC016845 BC068992 CH471106
GenPept AAH07639 AAH16845 AAH68992 CAC85951 EAW84116

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca